TRACKING EVOLUTION OF COLLAGEN SUBFAMILY FOR ITS UTMOST POSSIBLE BENEFIT

Abstract

The Collagen family is one of the most extensively researched protein families. However, because an evolutionary study has focused mostly on superfamilies, there is a paucity of information about subfamilies. To promote a healthy circulatory system, healthy skin through enhancing elasticity, and a healthy joint system, it is crucial that the subfamily of collagen evolve. Additionally, these kinds of studies support bone health, development against various developmental problems, and placenta growth in expectant women. The current research sought to comprehend collagen evolution on both a comprehensive and reductive level. The full family of human collagen proteins was exposed to BLAST techniques to identify orthologs and paralogs with various criteria, followed by the creation of phylogenetic trees. Our findings unambiguously demonstrated that the most archaic collagen isoforms in higher eukaryotes are COL20A1HP and COL12A1HPa, which later diverged into other collagen family members, possibly as a result of various gene modification processes. Additionally, a site-specific selection pressure study utilizing the selection server revealed that COL4A isoforms are evolving more quickly than other types of collagen.